HNRNPL

Entrez Summary: N/A
UniProt Summary: Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 177/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	9/28
bone	7/26
breast	6/33
central nervous system	14/56
cervix	0/4
colorectal	3/17
esophagus	5/13
fibroblast	0/1
gastric	4/16
kidney	7/21
liver	2/20
lung	18/75
lymphocyte	5/16
ovary	6/26
pancreas	5/24
peripheral nervous system	2/16
plasma cell	8/15
prostate	0/1
skin	2/24
soft tissue	5/9
thyroid	2/2
upper aerodigestive	3/22
urinary tract	6/29
uterus	1/5

Expression Distribution

pre-mRNA intronic binding
ribonucleoprotein granule
regulation of alternative mRNA splicing, via spliceosome
regulation of mRNA splicing, via spliceosome
regulation of RNA splicing
regulation of mRNA processing
ribonucleoprotein complex
transcription regulatory region DNA binding
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
regulation of mRNA metabolic process
RNA splicing
mRNA processing
mRNA metabolic process
RNA processing
RNA binding
RNA metabolic process
membrane
gene expression