HOXB4

Entrez Summary: N/A
UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
IU1-C 25μM R04 exp183	-2.11
Temozolomide 200μM R04 exp189	-1.74

bone marrow development
hematopoietic stem cell differentiation
definitive hemopoiesis
positive regulation of stem cell differentiation
somatic stem cell division
spleen development
activating transcription factor binding
stem cell division
morphogenesis of an epithelial sheet
hematopoietic progenitor cell differentiation
embryonic skeletal system morphogenesis
regulation of stem cell differentiation
embryonic skeletal system development
stem cell differentiation
bone development
anterior/posterior pattern specification
skeletal system morphogenesis
embryonic organ morphogenesis
RNA polymerase II regulatory region sequence-specific DNA binding
regionalization
morphogenesis of an epithelium
embryonic organ development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
centrosome
cell division
skeletal system development
cell population proliferation
hemopoiesis
tissue morphogenesis
embryonic morphogenesis
hematopoietic or lymphoid organ development
chordate embryonic development
immune system development
embryo development ending in birth or egg hatching
negative regulation of transcription by RNA polymerase II
animal organ morphogenesis
positive regulation of cell differentiation
embryo development
epithelium development