HOXB5

Entrez Summary: N/A
UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Actinomycin-D 0.01μM R00 exp4	-1.75
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.71

endothelial cell differentiation
embryonic skeletal system morphogenesis
endothelium development
RNA polymerase II distal enhancer sequence-specific DNA binding
embryonic skeletal system development
fibrillar center
anterior/posterior pattern specification
skeletal system morphogenesis
embryonic organ morphogenesis
regionalization
embryonic organ development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
skeletal system development
embryonic morphogenesis
chordate embryonic development
embryo development ending in birth or egg hatching
epithelial cell differentiation
animal organ morphogenesis
embryo development
epithelium development
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
tissue development
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process