HOXD3

Entrez Summary: N/A
UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Sulforaphane 9μM R08 exp526 no dilution day6	-2.02
Tenofovir 10μM R07 exp405	-1.81
Vinorelbine 0.001μM R05 exp249	-1.77
Isonicotinamide 500μM R03 exp129	-1.71
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.7
Cidofovir 10μM R07 exp345	1.82
EPZ-5676 30μM R05 exp233	1.88

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glossopharyngeal nerve morphogenesis
glossopharyngeal nerve development
thyroid gland development
cranial nerve morphogenesis
aggresome
cranial nerve development
nerve development
embryonic skeletal system morphogenesis
endocrine system development
Notch signaling pathway
cell-matrix adhesion
embryonic skeletal system development
cartilage development
cell-substrate adhesion
anterior/posterior pattern specification
connective tissue development
skeletal system morphogenesis
nuclear body
embryonic organ morphogenesis
RNA polymerase II regulatory region sequence-specific DNA binding
regionalization
positive regulation of neuron differentiation
gland development
embryonic organ development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
positive regulation of neurogenesis
skeletal system development
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of nervous system development
positive regulation of cell development
embryonic morphogenesis
chordate embryonic development
transcription, DNA-templated
nucleic acid-templated transcription
embryo development ending in birth or egg hatching
RNA biosynthetic process
regulation of neuron differentiation
DNA-binding transcription factor activity
regulation of neurogenesis