HPGD

Entrez Summary: This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

15-hydroxyprostaglandin dehydrogenase (NAD+) activity
prostaglandin E receptor activity
ductus arteriosus closure
lipoxin metabolic process
lipoxin biosynthetic process
thrombin-activated receptor signaling pathway
parturition
lipoxygenase pathway
NAD+ binding
ovulation
long-chain fatty acid biosynthetic process
positive regulation of vascular smooth muscle cell proliferation
prostaglandin metabolic process
prostanoid metabolic process
NAD binding
unsaturated fatty acid biosynthetic process
catalytic activity
icosanoid biosynthetic process
regulation of vascular smooth muscle cell proliferation
artery morphogenesis
artery development
positive regulation of smooth muscle cell proliferation
fatty acid derivative biosynthetic process
transforming growth factor beta receptor signaling pathway
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
response to ethanol
female gamete generation
regulation of smooth muscle cell proliferation
response to estradiol
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
fatty acid derivative metabolic process
female pregnancy
monocarboxylic acid biosynthetic process
basolateral plasma membrane
transmembrane receptor protein serine/threonine kinase signaling pathway
multi-multicellular organism process