HRK

Entrez Summary: N/A
UniProt Summary: Promotes apoptosis. {ECO:0000269|PubMed:15031724, ECO:0000269|PubMed:9130713}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of protein homooligomerization
regulation of protein homooligomerization
positive regulation of protein oligomerization
positive regulation of release of cytochrome c from mitochondria
regulation of protein oligomerization
regulation of release of cytochrome c from mitochondria
positive regulation of mitochondrion organization
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
positive regulation of protein complex assembly
regulation of apoptotic signaling pathway
regulation of protein complex assembly
positive regulation of cellular component biogenesis
positive regulation of organelle organization
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
apoptotic process
regulation of cellular component biogenesis
programmed cell death
cell death
positive regulation of cellular component organization
mitochondrion
regulation of organelle organization
regulation of apoptotic process
regulation of programmed cell death
positive regulation of signal transduction
regulation of cell death
positive regulation of cell communication
positive regulation of signaling