HSBP1

Entrez Summary: N/A
UniProt Summary: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular heat acclimation
heat acclimation
endodermal cell differentiation
endoderm formation
cellular response to heat
endoderm development
regulation of cellular response to heat
response to heat
formation of primary germ layer
gastrulation
response to temperature stimulus
transcription corepressor activity
muscle contraction
muscle system process
cytoskeleton
embryonic morphogenesis
regulation of cellular response to stress
negative regulation of transcription by RNA polymerase II
anatomical structure formation involved in morphogenesis
embryo development
identical protein binding
response to abiotic stimulus
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
regulation of response to stress
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
cellular response to stress
negative regulation of gene expression
tissue development
system process