HSPA13

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.34
Cyclosporin-A 3μM R07 exp348	-2.13
Lapatinib 5μM R01 exp47	-2.04
VHL-ligand-1 20μM R07 exp421	-2.02
Fluvastatin 2.2μM R06 exp282	-1.96
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.78
CVT-10216 0.1μM R06 exp278	-1.7
Azithromycin 100μM R08 exp452	1.72
Doxorubicin 0.02μM R08 exp478	1.72
Ibrutinib 10μM R08 exp442	1.79
Actinomycin-D 0.001μM R00 exp3	1.95
AICAR 240μM R03 exp116	2.38
Benzoate 10000μM R08 exp455	2.42

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

HSP70
MreB Mbl

endoplasmic reticulum chaperone complex
ATPase activity, coupled
protein folding chaperone
misfolded protein binding
chaperone cofactor-dependent protein refolding
protein refolding
de novo posttranslational protein folding
de novo protein folding
chaperone-mediated protein folding
heat shock protein binding
cellular response to heat
ubiquitin-dependent ERAD pathway
ERAD pathway
endoplasmic reticulum unfolded protein response
response to heat
cellular response to unfolded protein
unfolded protein binding
cellular response to topologically incorrect protein
response to unfolded protein
response to temperature stimulus
response to topologically incorrect protein
protein folding
ATPase activity
response to endoplasmic reticulum stress
endoplasmic reticulum lumen
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
intracellular membrane-bounded organelle
cellular macromolecule catabolic process
response to organonitrogen compound
macromolecule catabolic process
organonitrogen compound catabolic process
response to nitrogen compound
response to abiotic stimulus