HTATIP2

Entrez Summary: N/A
UniProt Summary: Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. {ECO:0000269|PubMed:10611237, ECO:0000269|PubMed:11313954, ECO:0000269|PubMed:15282309, ECO:0000269|PubMed:9174052}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

import into nucleus
oxidoreductase activity
nuclear envelope
nucleocytoplasmic transport
nuclear transport
transcription coactivator activity
regulation of angiogenesis
angiogenesis
regulation of vasculature development
blood vessel morphogenesis
blood vessel development
vasculature development
cardiovascular system development
tube morphogenesis
viral process
symbiotic process
interspecies interaction between organisms
tube development
circulatory system development
negative regulation of apoptotic process
anatomical structure formation involved in morphogenesis
negative regulation of programmed cell death
apoptotic process
oxidation-reduction process
negative regulation of cell death
programmed cell death
regulation of anatomical structure morphogenesis
cell death
intracellular transport
regulation of apoptotic process
regulation of programmed cell death
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of cell death
positive regulation of RNA metabolic process
establishment of localization in cell
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
membrane