HTR1E

Entrez Summary: N/A
UniProt Summary: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

serotonin binding
G protein-coupled serotonin receptor activity
G protein-coupled serotonin receptor signaling pathway
neurotransmitter receptor activity
serotonin receptor signaling pathway
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to catecholamine stimulus
cellular response to monoamine stimulus
response to catecholamine
response to monoamine
cellular response to ammonium ion
response to ammonium ion
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
cellular response to drug
dendrite
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
cellular response to organic cyclic compound
cellular response to organonitrogen compound
cellular response to nitrogen compound
G protein-coupled receptor activity
response to organic cyclic compound
response to organonitrogen compound
response to drug
cellular response to oxygen-containing compound
response to nitrogen compound
cell-cell signaling
cellular response to endogenous stimulus
G protein-coupled receptor signaling pathway
integral component of plasma membrane
response to endogenous stimulus
response to oxygen-containing compound