HTR5A

Entrez Summary: The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008].
UniProt Summary: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adenylate cyclase-inhibiting serotonin receptor signaling pathway
serotonin binding
integral component of postsynaptic specialization membrane
G protein-coupled serotonin receptor signaling pathway
G protein-coupled serotonin receptor activity
neurotransmitter receptor activity
serotonin receptor signaling pathway
rough endoplasmic reticulum
hippocampus development
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to monoamine stimulus
cellular response to catecholamine stimulus
response to monoamine
response to catecholamine
limbic system development
cellular response to ammonium ion
perikaryon
response to estradiol
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
pallium development
response to ammonium ion
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
telencephalon development
second-messenger-mediated signaling
forebrain development
cellular response to drug
chemical synaptic transmission
anterograde trans-synaptic signaling
dendrite
trans-synaptic signaling
synaptic signaling
cellular response to organic cyclic compound
cellular response to organonitrogen compound
cellular response to nitrogen compound
G protein-coupled receptor activity