HYPK

Gene Information
  • Official Symbol: HYPK
  • Official Name: huntingtin interacting protein K
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 25764
  • UniProt: Q9NX55
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation. {ECO:0000269|PubMed:17947297, ECO:0000269|PubMed:20154145}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 2040
  • Expression level (log2 read counts): 5.76

Expression Distribution

  • Last modified: 2026/01/07 22:36
  • by 127.0.0.1