IBSP

Entrez Summary: N/A
UniProt Summary: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Doxycycline 10μM R00 exp18	1.8
Quercetin 20μM R08 exp517	1.84

bone mineralization
biomineralization
biomineral tissue development
osteoblast differentiation
integrin binding
vesicle
ossification
extracellular matrix organization
extracellular structure organization
positive regulation of cell adhesion
cellular response to growth factor stimulus
response to growth factor
regulation of cell adhesion
molecular function
cell adhesion
biological adhesion
extracellular space
tissue development
extracellular region
membrane