IFIT2
Gene Information
- Official Symbol: IFIT2
- Official Name: interferon induced protein with tetratricopeptide repeats 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 3433
- UniProt: P09913
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. {ECO:0000269|PubMed:21190939}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16832
- Expression level (log2 read counts): 2.95
IFIT2 Expression in NALM6 Cells: 2.95
