IL10RA

Entrez Summary: The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009].
UniProt Summary: Receptor for IL10; binds IL10 with a high affinity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Milciclib 2μM R08 exp502	1.7
Monensin 0.3μM R08 exp507	1.92

interleukin-10 binding
interleukin-10 receptor activity
ubiquitin-dependent endocytosis
cytokine receptor activity
negative regulation of autophagy
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
signaling receptor activity
regulation of synapse organization
regulation of synapse structure or activity
negative regulation of cellular catabolic process
negative regulation of catabolic process
response to lipopolysaccharide
response to molecule of bacterial origin
regulation of autophagy
establishment of protein localization to organelle
endocytosis
cytokine-mediated signaling pathway
import into cell
response to bacterium
protein localization to organelle
regulation of cellular catabolic process
response to lipid
regulation of catabolic process
cellular response to cytokine stimulus
response to cytokine
response to other organism
response to external biotic stimulus
response to biotic stimulus
protein transport
peptide transport
response to oxygen-containing compound
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of signal transduction
positive regulation of cell communication