IL17RE

Entrez Summary: N/A
UniProt Summary: Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. {ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:21993849}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dynasore 10μM R04 exp180	-2.19
Geldanamycin 0.01μM R05 exp235	-1.79
All-trans-Retinoic-Acid 8μM R07 exp333	-1.7
DKK1 89ng/ml R08 exp477	1.7
THZ531 0.11μM R07 exp409	1.7
Cadmium 60μM R08 exp462	1.77

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

interleukin-17 receptor activity
interleukin-17-mediated signaling pathway
cellular response to interleukin-17
response to interleukin-17
inflammatory response
cytokine-mediated signaling pathway
cellular response to cytokine stimulus
response to cytokine
defense response
extracellular region