IL18R1

Gene Information

Official Symbol: IL18R1
Official Name: interleukin 18 receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 8809
UniProt: Q13478
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable) (PubMed:8626725). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). {ECO:0000250|UniProtKB:Q61098, ECO:0000269|PubMed:8626725, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12847
Expression level (log2 read counts): -1.82

Expression Distribution

Screen	Score
B02 10μM R08 exp453	-1.8
Brefeldin A 0.02μM R00 exp8	1.82
BI-6727 0.0125μM R03 exp97	1.86
Nutlin-3A 1.6μM R06 exp294	2.05

interleukin-18 binding
interleukin-18 receptor activity
interleukin-18 receptor complex
positive regulation of T-helper 1 cell cytokine production
regulation of T-helper 1 cell cytokine production
cellular response to interleukin-18
interleukin-18-mediated signaling pathway
interleukin-1 receptor activity
T-helper 1 cell differentiation
response to interleukin-18
T-helper 1 type immune response
positive regulation of T cell cytokine production
positive regulation of T-helper 1 type immune response
CD4-positive, alpha-beta T cell differentiation involved in immune response
T-helper cell differentiation
regulation of T-helper 1 type immune response
alpha-beta T cell activation involved in immune response
alpha-beta T cell differentiation involved in immune response
regulation of T cell cytokine production
T cell differentiation involved in immune response
CD4-positive, alpha-beta T cell differentiation
CD4-positive, alpha-beta T cell activation
negative regulation of cold-induced thermogenesis
positive regulation of T cell mediated immunity
alpha-beta T cell differentiation
positive regulation of cytokine production involved in immune response
natural killer cell activation
alpha-beta T cell activation
T cell activation involved in immune response
positive regulation of interferon-gamma production
regulation of T cell mediated immunity
positive regulation of NIK/NF-kappaB signaling
regulation of cytokine production involved in immune response
positive regulation of production of molecular mediator of immune response
regulation of interferon-gamma production
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
positive regulation of adaptive immune response
positive regulation of lymphocyte mediated immunity
regulation of NIK/NF-kappaB signaling
lymphocyte activation involved in immune response