IL1F10

Entrez Summary: N/A
UniProt Summary: Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2. {ECO:0000269|PubMed:22315422}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

interleukin-1 receptor binding
neutrophil chemotaxis
granulocyte chemotaxis
neutrophil migration
positive regulation of interleukin-6 production
granulocyte migration
myeloid leukocyte migration
positive regulation of JNK cascade
regulation of interleukin-6 production
leukocyte chemotaxis
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
cytokine activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to lipopolysaccharide
regulation of JNK cascade
cellular response to molecule of bacterial origin
cell chemotaxis
cellular response to biotic stimulus
regulation of stress-activated MAPK cascade
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of stress-activated protein kinase signaling cascade
response to lipopolysaccharide
response to molecule of bacterial origin
leukocyte migration
positive regulation of cytokine production
inflammatory response
cellular response to lipid
positive regulation of MAPK cascade
chemotaxis
taxis
cytokine-mediated signaling pathway
response to bacterium
regulation of cytokine production
regulation of cellular response to stress
regulation of MAPK cascade
response to lipid
cell migration
cellular response to cytokine stimulus
positive regulation of protein phosphorylation