IRX3

Entrez Summary: N/A
UniProt Summary: Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
NFN1 0.1μM R01 exp49	2.07
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.53
Ribavirin 10μM R01 exp52	2.61

Homeobox
Homeobox KN

specification of loop of Henle identity
specification of nephron tubule identity
proximal/distal pattern formation involved in nephron development
pattern specification involved in kidney development
renal system pattern specification
loop of Henle development
segment specification
nephron tubule formation
proximal/distal pattern formation
energy homeostasis
nephron tubule morphogenesis
nephron epithelium morphogenesis
nephron morphogenesis
renal tubule morphogenesis
nephron tubule development
renal tubule development
metanephros development
kidney morphogenesis
segmentation
nephron epithelium development
embryonic epithelial tube formation
nephron development
mesoderm development
kidney epithelium development
epithelial tube formation
morphogenesis of embryonic epithelium
tube formation
negative regulation of neuron differentiation
kidney development
renal system development
negative regulation of neurogenesis
axon
epithelial tube morphogenesis
negative regulation of nervous system development
urogenital system development
multicellular organismal homeostasis
regionalization
negative regulation of cell development
positive regulation of neuron differentiation
sequence-specific DNA binding