IST1

Entrez Summary: N/A
UniProt Summary: ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Latrunculin-B 10μM R07 exp374	-1.83
SB743921 0.001μM R05 exp244	1.79

viral capsid secondary envelopment
MIT domain binding
abscission
exit from host cell
movement in host environment
movement in environment of other organism involved in symbiotic interaction
exit from host
viral release from host cell
ESCRT III complex disassembly
ESCRT complex disassembly
positive regulation of collateral sprouting
regulation of collateral sprouting
Flemming body
multivesicular body assembly
multivesicular body organization
endoplasmic reticulum-Golgi intermediate compartment
endosome organization
positive regulation of axonogenesis
azurophil granule lumen
cytoskeleton-dependent cytokinesis
cytokinesis
regulation of extent of cell growth
chromatin
positive regulation of cell morphogenesis involved in differentiation
interaction with host
midbody
positive regulation of cell growth
positive regulation of developmental growth
nuclear envelope
regulation of cell size
regulation of axonogenesis
viral life cycle
protein-containing complex disassembly
protein domain specific binding
positive regulation of growth
protein-containing complex binding
positive regulation of neuron projection development
vesicle organization
regulation of cell morphogenesis involved in differentiation
cadherin binding