ISYNA1

Entrez Summary: This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Sucrose 20000μM R06 exp298	1.73
Betulinic acid 10 to 15μM on day4 R05 exp222	1.77
BH1 1μM R04 exp169	1.8

NAD binding 5
Inos-1-P synth

inositol-3-phosphate synthase activity
inositol biosynthetic process
inositol metabolic process
inositol phosphate metabolic process
cellular carbohydrate biosynthetic process
polyol biosynthetic process
polyol metabolic process
alcohol biosynthetic process
carbohydrate biosynthetic process
cellular carbohydrate metabolic process
organic hydroxy compound biosynthetic process
phospholipid biosynthetic process
alcohol metabolic process
phospholipid metabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
small molecule biosynthetic process
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
small molecule metabolic process