ITM2A

Entrez Summary: This gene encodes a type II membrane protein that belongs to the ITM2 family. Studies in mouse suggest that it may be involved in osteo- and chondrogenic differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

plasma cell differentiation
negative regulation of amyloid precursor protein biosynthetic process
negative regulation of glycoprotein biosynthetic process
regulation of amyloid precursor protein biosynthetic process
negative regulation of glycoprotein metabolic process
mature B cell differentiation involved in immune response
mature B cell differentiation
regulation of glycoprotein biosynthetic process
B cell activation involved in immune response
regulation of glycoprotein metabolic process
amyloid-beta binding
B cell differentiation
lymphocyte activation involved in immune response
B cell activation
immunoglobulin production
production of molecular mediator of immune response
lymphocyte differentiation
leukocyte differentiation
lymphocyte activation
hemopoiesis
hematopoietic or lymphoid organ development
leukocyte activation involved in immune response
cell activation involved in immune response
immune system development
leukocyte activation
Golgi apparatus
cell activation
immune effector process
negative regulation of protein metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
immune response