ITPRIP

Gene Information

Official Symbol: ITPRIP
Official Name: inositol 1,4,5-trisphosphate receptor interacting protein
Aliases and Previous Symbols: N/A
Entrez ID: 85450
UniProt: Q8IWB1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release. {ECO:0000269|PubMed:16990268}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9599
Expression level (log2 read counts): 5.89

Expression Distribution

Screen	Score
Milciclib 2μM R08 exp502	-1.94
Pomalidomide 20μM R07 exp391	1.76

protein kinase inhibitor activity
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway
negative regulation of apoptotic signaling pathway
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
regulation of apoptotic signaling pathway
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of transferase activity
negative regulation of cell death
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation
regulation of apoptotic process
regulation of programmed cell death
regulation of phosphorylation
negative regulation of response to stimulus
regulation of cell death
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
membrane