IVD

Entrez Summary: Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nifuroxazide 5μM R03 exp102	1.75
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.9

isovaleryl-CoA dehydrogenase activity
leucine catabolic process
leucine metabolic process
fatty acid beta-oxidation using acyl-CoA dehydrogenase
branched-chain amino acid metabolic process
branched-chain amino acid catabolic process
fatty acid beta-oxidation
flavin adenine dinucleotide binding
fatty acid oxidation
lipid oxidation
fatty acid catabolic process
alpha-amino acid catabolic process
monocarboxylic acid catabolic process
cellular amino acid catabolic process
cellular lipid catabolic process
lipid modification
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
cellular amino acid metabolic process
fatty acid metabolic process
mitochondrial matrix
small molecule catabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
lipid metabolic process
mitochondrion
small molecule metabolic process
organic substance catabolic process
cellular catabolic process