ETFA

Entrez Summary: ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199). {ECO:0000269|PubMed:10356313, ECO:0000269|PubMed:12815589, ECO:0000269|PubMed:1430199, ECO:0000269|PubMed:15159392, ECO:0000269|PubMed:15975918, ECO:0000269|PubMed:27499296, ECO:0000269|PubMed:9334218, ECO:0000303|PubMed:17941859, ECO:0000305|PubMed:1882842}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cadmium 60μM R08 exp462	1.79
Trichostatin-A 0.06μM R07 exp415	1.81
Nifuroxazide 5μM R03 exp102	1.82
LB-100 2μM R05 exp210	1.91
Hippuristanol 0.12μM R08 exp488	1.92
VHL-ligand-1 20μM R07 exp421	1.94
Nifuroxazide 1μM R01 exp51	1.98
Dexamethasone 0.006μM R07 exp351	2.01
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.01
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.05
Tunicamycin 0.04μM R07 exp418	2.42
Ethanol 0.01 R05 exp234	2.94

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ETF alpha
ETF

fatty acid beta-oxidation using acyl-CoA dehydrogenase
flavin adenine dinucleotide binding
fatty acid beta-oxidation
electron transfer activity
fatty acid oxidation
lipid oxidation
fatty acid catabolic process
respiratory electron transport chain
monocarboxylic acid catabolic process
oxidoreductase activity
cellular respiration
electron transport chain
cellular lipid catabolic process
lipid modification
energy derivation by oxidation of organic compounds
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
fatty acid metabolic process
mitochondrial matrix
generation of precursor metabolites and energy
small molecule catabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
mitochondrion
small molecule metabolic process
organic substance catabolic process
cellular catabolic process