JDP2

Gene Information

Official Symbol: JDP2
Official Name: Jun dimerization protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 122953
UniProt: Q8WYK2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. {ECO:0000269|PubMed:12707301, ECO:0000269|PubMed:12903123, ECO:0000269|PubMed:16026868, ECO:0000269|PubMed:16518400}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17903
Expression level (log2 read counts): 4.3

Expression Distribution

Screen	Score
Bisphenol S 100μM R08 exp458	-1.84
Nicotinamide Riboside 100μM R03 exp139	-1.75
SGC2043 10μM R03 exp152	-1.73

bZIP 2
bZIP 1

positive regulation of histone deacetylation
positive regulation of protein deacetylation
regulation of histone deacetylation
regulation of protein deacetylation
negative regulation of fat cell differentiation
positive regulation of histone modification
positive regulation of chromatin organization
regulation of fat cell differentiation
regulation of histone modification
positive regulation of chromosome organization
regulation of chromatin organization
transcription corepressor activity
DNA-binding transcription repressor activity, RNA polymerase II-specific
regulation of chromosome organization
chromatin binding
protein heterodimerization activity
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of organelle organization
negative regulation of cell differentiation
negative regulation of transcription by RNA polymerase II
negative regulation of developmental process
negative regulation of transcription, DNA-templated
positive regulation of cellular component organization
positive regulation of protein modification process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
regulation of organelle organization
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
negative regulation of gene expression
regulation of cell differentiation
regulation of protein modification process