KATNBL1

Entrez Summary: N/A
UniProt Summary: Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro. {ECO:0000269|PubMed:26929214}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cabazitaxel 0.001μM R05 exp223	-2.78
KU-0063794 3.8μM R02 exp71	1.72
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.79
BI-6727 0.0125μM R03 exp97	1.8

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitotic spindle pole
positive regulation of cytoskeleton organization
regulation of cytoskeleton organization
positive regulation of organelle organization
nucleolus
positive regulation of cellular component organization
regulation of organelle organization