KCNE1

Gene Information

Official Symbol: KCNE1
Official Name: potassium voltage-gated channel subfamily E regulatory subunit 1
Aliases and Previous Symbols: N/A
Entrez ID: 3753
UniProt: P15382
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). {ECO:0000269|PubMed:19219384}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6

Essentiality Rank: 13048
Expression level (log2 read counts): 2.14

Expression Distribution

negative regulation of protein targeting to membrane
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
telethonin binding
negative regulation of delayed rectifier potassium channel activity
membrane repolarization during ventricular cardiac muscle cell action potential
negative regulation of voltage-gated potassium channel activity
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
ventricular cardiac muscle cell membrane repolarization
potassium ion export across plasma membrane
cardiac muscle cell membrane repolarization
regulation of delayed rectifier potassium channel activity
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
negative regulation of potassium ion transmembrane transporter activity
membrane repolarization
ventricular cardiac muscle cell action potential
regulation of ventricular cardiac muscle cell membrane repolarization
negative regulation of potassium ion transmembrane transport
regulation of cardiac muscle cell membrane repolarization
negative regulation of protein localization to membrane
negative regulation of potassium ion transport
delayed rectifier potassium channel activity
regulation of membrane repolarization
regulation of protein targeting to membrane
positive regulation of potassium ion transmembrane transport
regulation of heart rate by cardiac conduction
export across plasma membrane
cardiac muscle cell action potential involved in contraction
potassium channel regulator activity
negative regulation of intracellular protein transport
cardiac muscle cell contraction
negative regulation of cation channel activity
positive regulation of potassium ion transport
cardiac muscle cell action potential
cellular response to cAMP
regulation of potassium ion transmembrane transporter activity
voltage-gated potassium channel activity
negative regulation of intracellular transport
negative regulation of ion transmembrane transporter activity
cardiac muscle contraction