KCNN2

Entrez Summary: N/A
UniProt Summary: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

small conductance calcium-activated potassium channel activity
membrane repolarization during atrial cardiac muscle cell action potential
atrial cardiac muscle cell membrane repolarization
calcium-activated potassium channel activity
atrial cardiac muscle cell to AV node cell signaling
atrial cardiac muscle cell action potential
atrial cardiac muscle cell to AV node cell communication
alpha-actinin binding
cardiac muscle cell membrane repolarization
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
membrane repolarization
cell-cell signaling involved in cardiac conduction
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
cell communication involved in cardiac conduction
cardiac muscle cell action potential
cardiac muscle contraction
regulation of potassium ion transmembrane transport
heart contraction
actin-mediated cell contraction
cardiac conduction
action potential
regulation of potassium ion transport
heart process
striated muscle contraction
actin filament-based movement
Z disc
multicellular organismal signaling
dendritic spine
potassium ion transmembrane transport
potassium ion transport
calmodulin binding
regulation of heart contraction
protein domain specific binding
muscle contraction
regulation of blood circulation
muscle system process
neuron projection
regulation of cation transmembrane transport