KIAA0368

Entrez Summary: N/A
UniProt Summary: Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis. {ECO:0000269|PubMed:15496406, ECO:0000269|PubMed:20682791}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

proteasome assembly
proteasome binding
multivesicular body
COPII-coated ER to Golgi transport vesicle
molecular adaptor activity
proteasome complex
endocytic vesicle
ubiquitin-dependent ERAD pathway
endoplasmic reticulum-Golgi intermediate compartment
ERAD pathway
late endosome
trans-Golgi network
cytoplasmic vesicle
early endosome
response to endoplasmic reticulum stress
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
centrosome
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
cellular protein-containing complex assembly
cellular macromolecule catabolic process
response to organonitrogen compound
endoplasmic reticulum
macromolecule catabolic process
organonitrogen compound catabolic process
response to nitrogen compound
proteolysis
protein-containing complex assembly
cellular response to stress
organic substance catabolic process
cellular catabolic process
protein-containing complex subunit organization
membrane