KIAA1199

Gene Information

Official Symbol: CEMIP
Official Name: cell migration inducing hyaluronidase 1
Aliases and Previous Symbols: N/A
Entrez ID: 57214
UniProt: Q8WUJ3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial- mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC- dependent manner. May be involved in hearing. {ECO:0000269|PubMed:23509262, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:24269685}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4270
Expression level (log2 read counts): 1.14

Expression Distribution

Screen	Score
Zebularine 20μM R07 exp423	-1.82
Selumetinib 20μM R02 exp81	1.94

ER retention sequence binding
positive regulation of protein kinase C activity
regulation of protein kinase C activity
hyaluronan biosynthetic process
clathrin heavy chain binding
hyalurononglucosaminidase activity
hyaluronan catabolic process
hyaluronic acid binding
clathrin-coated endocytic vesicle
positive regulation of peptidyl-threonine phosphorylation
hyaluronan metabolic process
positive regulation of protein targeting to membrane
regulation of protein targeting to membrane
positive regulation of release of sequestered calcium ion into cytosol
regulation of peptidyl-threonine phosphorylation
clathrin-coated vesicle membrane
positive regulation of calcium ion transport into cytosol
clathrin-coated pit
glycosaminoglycan catabolic process
aminoglycan catabolic process
positive regulation of calcium ion transmembrane transport
regulation of release of sequestered calcium ion into cytosol
regulation of protein targeting
regulation of calcium ion transport into cytosol
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
positive regulation of calcium ion transport
positive regulation of protein localization to membrane
regulation of sequestering of calcium ion
positive regulation of cation transmembrane transport
sensory perception of sound
regulation of calcium ion transmembrane transport
positive regulation of intracellular protein transport
positive regulation of ion transmembrane transport
glycosaminoglycan metabolic process
aminoglycan metabolic process
sensory perception of mechanical stimulus
regulation of protein localization to membrane
carbohydrate derivative catabolic process