KIR2DL4

Gene Information

Official Symbol: KIR2DL4
Official Name: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
Aliases and Previous Symbols: N/A
Entrez ID: 3805
UniProt: Q99706
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mubritinib 0.2μM R01 exp48	-2.07
CR131-b 0.005μM R08 exp474	-1.79
Tubastatin-A 2.5μM R07 exp417	1.77
Cincreasin 100μM R08 exp473	1.81
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	2.05
Deferoxamine 11μM R07 exp350	2.36

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14044
Expression level (log2 read counts): 3.55

Expression Distribution

MHC class Ib receptor activity
positive regulation of natural killer cell cytokine production
regulation of natural killer cell cytokine production
positive regulation of cellular senescence
negative regulation of natural killer cell mediated cytotoxicity
positive regulation of cell aging
negative regulation of natural killer cell mediated immunity
negative regulation of leukocyte mediated cytotoxicity
negative regulation of cell killing
positive regulation of natural killer cell mediated immunity
negative regulation of lymphocyte mediated immunity
regulation of cellular senescence
regulation of natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated immunity
regulation of cell aging
negative regulation of leukocyte mediated immunity
cellular defense response
positive regulation of cytokine production involved in immune response
negative regulation of innate immune response
regulation of leukocyte mediated cytotoxicity
regulation of cytokine production involved in immune response
negative regulation of response to biotic stimulus
positive regulation of production of molecular mediator of immune response
regulation of cell killing
positive regulation of lymphocyte mediated immunity
negative regulation of immune effector process
positive regulation of leukocyte mediated immunity
transmembrane signaling receptor activity
regulation of production of molecular mediator of immune response
negative regulation of immune response
regulation of lymphocyte mediated immunity
early endosome membrane
regulation of leukocyte mediated immunity
negative regulation of defense response
negative regulation of multi-organism process
positive regulation of immune effector process
positive regulation of innate immune response
positive regulation of response to biotic stimulus
negative regulation of response to external stimulus
negative regulation of immune system process