KLB

Gene Information

Official Symbol: KLB
Official Name: klotho beta
Aliases and Previous Symbols: N/A
Entrez ID: 152831
UniProt: Q86Z14
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15549
Expression level (log2 read counts): 2.61

Expression Distribution

Screen	Score
Resveratrol 16μM R03 exp147	-1.74
Rifampicin 30μM R08 exp430	-1.71
Q15 2.7μM R02 exp79	1.86

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
hydrolase activity, hydrolyzing O-glycosyl compounds
fibroblast growth factor receptor binding
fibroblast growth factor binding
fibroblast growth factor receptor signaling pathway
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
positive regulation of protein kinase B signaling
regulation of protein kinase B signaling
MAPK cascade
signal transduction by protein phosphorylation
carbohydrate metabolic process
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
positive regulation of MAPK cascade
enzyme linked receptor protein signaling pathway
regulation of MAPK cascade
positive regulation of cell population proliferation
protein phosphorylation
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
cellular response to endogenous stimulus
positive regulation of protein modification process
phosphorylation
regulation of protein phosphorylation
response to endogenous stimulus
regulation of phosphorylation
positive regulation of cellular protein metabolic process
regulation of cell population proliferation
positive regulation of signal transduction
intracellular signal transduction
positive regulation of protein metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of cell communication
positive regulation of signaling