KRR1

Entrez Summary: N/A
UniProt Summary: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 597/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	19/28
bone	18/26
breast	24/33
central nervous system	50/56
cervix	4/4
colorectal	12/17
esophagus	11/13
fibroblast	1/1
gastric	13/16
kidney	20/21
liver	15/20
lung	63/75
lymphocyte	8/16
ovary	21/26
pancreas	23/24
peripheral nervous system	14/16
plasma cell	10/15
prostate	0/1
skin	19/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	17/22
urinary tract	27/29
uterus	3/5

Expression Distribution

small-subunit processome
intercellular bridge
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
membrane
gene expression