KRT18

Entrez Summary: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Golgi to plasma membrane CFTR protein transport
hepatocyte apoptotic process
cadherin binding involved in cell-cell adhesion
epithelial cell apoptotic process
centriolar satellite
Golgi to plasma membrane protein transport
cell periphery
intermediate filament cytoskeleton organization
intermediate filament-based process
establishment of protein localization to plasma membrane
scaffold protein binding
Golgi to plasma membrane transport
vesicle-mediated transport to the plasma membrane
extrinsic apoptotic signaling pathway
keratin filament
post-Golgi vesicle-mediated transport
cell-cell adherens junction
cornification
intermediate filament
tumor necrosis factor-mediated signaling pathway
microtubule organizing center
protein localization to plasma membrane
structural molecule activity
protein localization to cell periphery
keratinization
cellular response to tumor necrosis factor
response to tumor necrosis factor
establishment of protein localization to membrane
keratinocyte differentiation
apoptotic signaling pathway
epidermal cell differentiation
Golgi vesicle transport
skin development
epidermis development
protein localization to membrane
cell-cell adhesion
cytokine-mediated signaling pathway
epithelial cell differentiation
perinuclear region of cytoplasm
viral process