LALBA

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BI-2536 0.001μM R01 exp41	1.82
Taxol 0.002μM R01 exp54	2.16

lactose synthase activity
lactose metabolic process
lactose biosynthetic process
disaccharide biosynthetic process
disaccharide metabolic process
oligosaccharide biosynthetic process
oligosaccharide metabolic process
cellular carbohydrate biosynthetic process
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
Golgi lumen
carbohydrate biosynthetic process
cellular carbohydrate metabolic process
defense response to bacterium
carbohydrate metabolic process
Golgi membrane
response to bacterium
calcium ion binding
apoptotic process
defense response to other organism
programmed cell death
cell death
cell-cell signaling
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
extracellular space