LARP4

Entrez Summary: N/A
UniProt Summary: RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

poly(A) binding
polysome
cytosolic small ribosomal subunit
cytoplasmic stress granule
positive regulation of translation
positive regulation of cellular amide metabolic process
regulation of translation
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
regulation of cell morphogenesis
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
regulation of anatomical structure morphogenesis
cytoskeleton organization
RNA binding
organonitrogen compound biosynthetic process
positive regulation of cellular protein metabolic process
cellular nitrogen compound biosynthetic process
positive regulation of protein metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
membrane
gene expression
positive regulation of biosynthetic process