LEPRE1

Entrez Summary: This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

procollagen-proline 3-dioxygenase activity
negative regulation of post-translational protein modification
regulation of post-translational protein modification
peptidyl-proline hydroxylation
L-ascorbic acid binding
protein hydroxylation
chaperone-mediated protein folding
peptidyl-proline modification
collagen binding
collagen metabolic process
iron ion binding
protein stabilization
bone development
protein folding
positive regulation of neuron projection development
regulation of protein stability
endoplasmic reticulum lumen
collagen-containing extracellular matrix
positive regulation of neuron differentiation
positive regulation of cell projection organization
regulation of protein secretion
positive regulation of neurogenesis
regulation of peptide secretion
skeletal system development
regulation of neuron projection development
positive regulation of nervous system development
positive regulation of cell development
negative regulation of protein modification process
protein-containing complex
regulation of neuron differentiation
negative regulation of cell population proliferation
regulation of plasma membrane bounded cell projection organization
regulation of protein transport
regulation of cell projection organization
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
molecular function
regulation of secretion
regulation of neurogenesis