LHPP

Official Symbol: LHPP
Official Name: phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Aliases and Previous Symbols: N/A
Entrez ID: 64077
UniProt: Q9H008
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CCT251545 20μM R07 exp326	-2.42
GSK-LSD1 10μM R03 exp123	-1.74

protein histidine phosphatase activity
inorganic diphosphatase activity
purine nucleoside monophosphate biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
ribonucleoside monophosphate biosynthetic process
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
nucleoside monophosphate biosynthetic process
phosphatase activity
ribonucleoside monophosphate metabolic process
nucleoside monophosphate metabolic process
protein dephosphorylation
magnesium ion binding
nucleoside phosphate biosynthetic process
dephosphorylation
nuclear speck
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
protein homodimerization activity
organophosphate metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process