LHX8

Entrez Summary: N/A
UniProt Summary: Transcription factor involved in differentiation of certain neurons and mesenchymal cells. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox
LIM

female germ cell nucleus
forebrain neuron development
forebrain neuron differentiation
forebrain generation of neurons
central nervous system neuron development
odontogenesis of dentin-containing tooth
female gonad development
development of primary female sexual characteristics
female sex differentiation
odontogenesis
central nervous system neuron differentiation
gonad development
development of primary sexual characteristics
learning or memory
sex differentiation
cognition
RNA polymerase II regulatory region sequence-specific DNA binding
forebrain development
reproductive structure development
reproductive system development
behavior
developmental process involved in reproduction
brain development
head development
neuron development
animal organ morphogenesis
central nervous system development
neuron differentiation
positive regulation of transcription by RNA polymerase II
nervous system process
reproductive process
reproduction
generation of neurons
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cell development
positive regulation of RNA metabolic process