LILRA4

Gene Information

Official Symbol: LILRA4
Official Name: leukocyte immunoglobulin like receptor A4
Aliases and Previous Symbols: N/A
Entrez ID: 23547
UniProt: P59901
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine- phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down- regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760). {ECO:0000269|PubMed:16735691, ECO:0000269|PubMed:19564354, ECO:0000269|PubMed:24586760, ECO:0000269|PubMed:26172439}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14012
Expression level (log2 read counts): 1.83

Expression Distribution

Screen	Score
L-74142 5μM R03 exp131	-1.79
BI-2536 0.001μM R01 exp41	1.94

negative regulation of toll-like receptor 7 signaling pathway
regulation of toll-like receptor 7 signaling pathway
Fc-epsilon receptor I complex
negative regulation of toll-like receptor 9 signaling pathway
negative regulation of interferon-alpha production
regulation of toll-like receptor 9 signaling pathway
regulation of interferon-alpha production
coreceptor activity
negative regulation of toll-like receptor signaling pathway
negative regulation of type I interferon production
negative regulation of tumor necrosis factor production
negative regulation of tumor necrosis factor superfamily cytokine production
regulation of toll-like receptor signaling pathway
regulation of type I interferon production
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
Fc-epsilon receptor signaling pathway
Fc receptor signaling pathway
negative regulation of cytokine production
signaling receptor binding
negative regulation of immune system process
regulation of innate immune response
immune response-regulating cell surface receptor signaling pathway
regulation of response to biotic stimulus
immune response-regulating signaling pathway
regulation of cytokine production
regulation of defense response
innate immune response
regulation of multi-organism process
defense response to other organism
regulation of response to external stimulus
regulation of immune response
negative regulation of multicellular organismal process
negative regulation of signal transduction
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
negative regulation of cell communication
negative regulation of signaling