LIMCH1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BRD2 inhibitor II 20μM R07 exp341	-1.75
Myriocin 25μM R06 exp293	1.86

CH
LIM

myosin II head/neck binding
myosin II complex
positive regulation of stress fiber assembly
regulation of focal adhesion assembly
regulation of cell-substrate junction assembly
positive regulation of actin filament bundle assembly
regulation of adherens junction organization
stress fiber
regulation of stress fiber assembly
regulation of actomyosin structure organization
regulation of cell junction assembly
regulation of actin filament bundle assembly
regulation of cell-matrix adhesion
actomyosin structure organization
positive regulation of supramolecular fiber organization
regulation of cell-substrate adhesion
positive regulation of cytoskeleton organization
negative regulation of cell migration
regulation of actin filament organization
actin binding
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
regulation of actin filament-based process
actin cytoskeleton organization
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
actin filament-based process
positive regulation of organelle organization
regulation of cell adhesion
regulation of cell migration
regulation of cell motility
regulation of cellular component biogenesis
regulation of locomotion
regulation of cellular component movement
positive regulation of protein phosphorylation
positive regulation of phosphorylation
cytoskeleton organization