LMAN2

Entrez Summary: N/A
UniProt Summary: Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mannose binding
COPII-coated ER to Golgi transport vesicle
endoplasmic reticulum organization
heat shock protein binding
positive regulation of phagocytosis
endoplasmic reticulum-Golgi intermediate compartment membrane
endoplasmic reticulum-Golgi intermediate compartment
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
regulation of phagocytosis
Golgi organization
carbohydrate binding
endoplasmic reticulum to Golgi vesicle-mediated transport
Golgi vesicle transport
endomembrane system organization
regulation of vesicle-mediated transport
cell surface
Golgi membrane
endoplasmic reticulum membrane
Golgi apparatus
positive regulation of transport
integral component of plasma membrane
protein transport
intracellular transport
peptide transport
amide transport
extracellular space
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
regulation of transport
vesicle-mediated transport