LOH12CR1

Entrez Summary: N/A
UniProt Summary: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility. {ECO:0000269|PubMed:25898167}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Epothilone-B 0.0015μM R05 exp231	1.77
Bisphenol A 100μM R06 exp269	1.8

positive regulation of synaptic vesicle transport
positive regulation of anterograde synaptic vesicle transport
plus-end kinesin complex
regulation of anterograde synaptic vesicle transport
positive regulation of vesicle transport along microtubule
regulation of vesicle transport along microtubule
cytoplasmic side of lysosomal membrane
regulation of synaptic vesicle transport
BORC complex
regulation of organelle transport along microtubule
intrinsic component of membrane
regulation of microtubule-based movement
lysosome localization
synaptic vesicle membrane
organelle transport along microtubule
transport along microtubule
cytoskeleton-dependent intracellular transport
microtubule-based transport
positive regulation of intracellular transport
regulation of microtubule-based process
microtubule-based movement
regulation of intracellular transport
establishment of organelle localization
positive regulation of cellular component movement
organelle localization
microtubule-based process
regulation of cellular localization
positive regulation of transport
regulation of cellular component movement
intracellular transport
movement of cell or subcellular component
establishment of localization in cell
regulation of transport