LPAR2

Entrez Summary: N/A
UniProt Summary: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. {ECO:0000269|PubMed:15143197, ECO:0000269|PubMed:19306925}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

7TM GPCR Srsx
7tm 1

lysophosphatidic acid receptor activity
activation of phospholipase C activity
positive regulation of phospholipase C activity
regulation of phospholipase C activity
endocytic vesicle
positive regulation of phospholipase activity
regulation of phospholipase activity
positive regulation of lipase activity
regulation of lipase activity
lipid binding
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
cell surface
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
G protein-coupled receptor activity
cellular chemical homeostasis
positive regulation of hydrolase activity
ion homeostasis
cellular homeostasis
chemical homeostasis
regulation of hydrolase activity
G protein-coupled receptor signaling pathway
integral component of plasma membrane
positive regulation of catalytic activity
homeostatic process
positive regulation of molecular function