LPXN

Entrez Summary: N/A
UniProt Summary: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18451096, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:20543562}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 0.1μM R01 exp49	-2.1
Epigallocatechin gallate 20μM R05 exp230	1.72
Ethanol 0.01 R05 exp234	1.72
Metformin 100 to 150μM on day4 R04 exp170	1.83
Oligomycin-A 2μM R00 exp25	1.91

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of B cell receptor signaling pathway
regulation of B cell receptor signaling pathway
negative regulation of antigen receptor-mediated signaling pathway
podosome
regulation of cell adhesion mediated by integrin
regulation of antigen receptor-mediated signaling pathway
transcription coregulator activity
cell projection
negative regulation of cell adhesion
nuclear speck
focal adhesion
negative regulation of immune system process
regulation of cell adhesion
perinuclear region of cytoplasm
cell adhesion
biological adhesion
regulation of immune response
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
protein-containing complex assembly
negative regulation of response to stimulus
regulation of immune system process
protein-containing complex subunit organization
membrane