LRP6

Gene Information

Official Symbol: LRP6
Official Name: LDL receptor related protein 6
Aliases and Previous Symbols: N/A
Entrez ID: 4040
UniProt: O75581
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009].
UniProt Summary: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11408
Expression level (log2 read counts): 5.8

Expression Distribution

Screen	Score
Milciclib 2μM R08 exp502	1.72
Monensin 0.3μM R08 exp507	2.1
Sulforaphane 9μM R08 exp526 no dilution day6	2.14

Ldl recept a
Ldl recept b

canonical Wnt signaling pathway involved in neural crest cell differentiation
external genitalia morphogenesis
coreceptor activity involved in Wnt signaling pathway
coreceptor activity involved in canonical Wnt signaling pathway
receptor-mediated endocytosis involved in cholesterol transport
axis elongation involved in somitogenesis
Wnt-Frizzled-LRP5/6 complex
trachea cartilage morphogenesis
canonical Wnt signaling pathway involved in regulation of cell proliferation
Wnt signaling pathway involved in somitogenesis
kinase inhibitor activity
toxin transmembrane transporter activity
negative regulation of smooth muscle cell apoptotic process
embryonic retina morphogenesis in camera-type eye
trachea cartilage development
pericardium morphogenesis
midbrain-hindbrain boundary development
primitive streak formation
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
neural crest formation
trachea morphogenesis
midbrain dopaminergic neuron differentiation
rostrocaudal neural tube patterning
low-density lipoprotein particle receptor activity
Wnt signalosome
thalamus development
genitalia morphogenesis
convergent extension
apolipoprotein binding
intracellular cholesterol transport
cellular response to cholesterol
intracellular sterol transport
Wnt-activated receptor activity
trachea development
pericardium development
cellular response to sterol
beta-catenin destruction complex disassembly
branching involved in mammary gland duct morphogenesis
regulation of smooth muscle cell apoptotic process
response to cholesterol