LRPAP1

Entrez Summary: This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
UniProt Summary: Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. {ECO:0000269|PubMed:7774585}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Alpha-2-MRAP C
Alpha-2-MRAP N

rough endoplasmic reticulum lumen
regulation of very-low-density lipoprotein particle clearance
very-low-density lipoprotein particle receptor binding
negative regulation of very-low-density lipoprotein particle clearance
lipase binding
amyloid-beta clearance by transcytosis
positive regulation of amyloid-beta clearance
negative regulation of lipoprotein particle clearance
negative regulation of amyloid-beta clearance
extracellular negative regulation of signal transduction
extracellular regulation of signal transduction
negative regulation of receptor internalization
regulation of amyloid-beta clearance
endosome lumen
transcytosis
regulation of lipoprotein particle clearance
low-density lipoprotein particle receptor binding
amyloid-beta clearance
negative regulation of receptor-mediated endocytosis
receptor antagonist activity
negative regulation of endocytosis
regulation of receptor internalization
negative regulation of signaling receptor activity
cis-Golgi network
endoplasmic reticulum-Golgi intermediate compartment
amyloid-beta binding
regulation of receptor-mediated endocytosis
Golgi lumen
negative regulation of protein binding
negative regulation of binding
heparin binding
regulation of signaling receptor activity
regulation of endocytosis
regulation of protein binding
endosome
signaling receptor binding
regulation of binding
negative regulation of transport
regulation of vesicle-mediated transport
cell surface