LRRC32
Gene Information
- Official Symbol: LRRC32
- Official Name: leucine rich repeat containing 32
- Aliases and Previous Symbols: N/A
- Entrez ID: 2615
- UniProt: Q14392
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| LRR 4 |
GO Terms
| regulation of transforming growth factor beta3 activation |
| regulation of transforming growth factor beta3 production |
| regulation of transforming growth factor beta activation |
| negative regulation of activated T cell proliferation |
| transforming growth factor beta binding |
| secondary palate development |
| regulation of transforming growth factor beta production |
| regulation of activated T cell proliferation |
| negative regulation of T cell proliferation |
| negative regulation of cytokine secretion |
| negative regulation of lymphocyte proliferation |
| negative regulation of mononuclear cell proliferation |
| negative regulation of leukocyte proliferation |
| roof of mouth development |
| transforming growth factor beta receptor signaling pathway |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| negative regulation of protein secretion |
| negative regulation of peptide secretion |
| negative regulation of lymphocyte activation |
| cellular response to transforming growth factor beta stimulus |
| regulation of T cell proliferation |
| response to transforming growth factor beta |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| negative regulation of cell activation |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of leukocyte proliferation |
| negative regulation of secretion |
| extracellular matrix |
| negative regulation of cell adhesion |
| negative regulation of cytokine production |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| regulation of cell-cell adhesion |
| negative regulation of immune system process |
| regulation of protein secretion |
| negative regulation of transport |
| regulation of peptide secretion |
| cellular response to growth factor stimulus |
| regulation of lymphocyte activation |
| response to growth factor |
| regulation of leukocyte activation |
| cell surface |
| regulation of cell activation |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulation of cytokine production |
| regulation of protein transport |
| enzyme linked receptor protein signaling pathway |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| regulation of protein localization |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| integral component of plasma membrane |
| response to endogenous stimulus |
| extracellular space |
| regulation of cell population proliferation |
| regulation of immune system process |
| regulation of transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Vemurafenib 6.6μM R08 exp434 | -2.1 |
| Hydroxyurea 100μM R07 exp329 | 1.9 |
| Alpha-Amanitin 0.5μM R00 exp5 | 1.93 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12087
- Expression level (log2 read counts): -3.28
Expression Distribution
LRRC32 Expression in NALM6 Cells: -3.28
