LRRC7
Gene Information
- Official Symbol: LRRC7
- Official Name: leucine rich repeat containing 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 57554
- UniProt: Q96NW7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. {ECO:0000269|PubMed:11729199}.
Pfam Domains GO Terms
Pfam Domains
| PDZ |
| LRR 4 |
GO Terms
| neurotransmitter receptor transport postsynaptic membrane to endosome |
| protein localization to early endosome |
| neurotransmitter receptor transport, endosome to plasma membrane |
| neurotransmitter receptor transport, endosome to postsynaptic membrane |
| endosome to plasma membrane protein transport |
| protein localization to endosome |
| ionotropic glutamate receptor complex |
| neurotransmitter receptor transport to postsynaptic membrane |
| neurotransmitter receptor transport to plasma membrane |
| establishment of protein localization to postsynaptic membrane |
| axon initial segment |
| retrograde transport, endosome to plasma membrane |
| ionotropic glutamate receptor binding |
| neurotransmitter receptor transport |
| protein localization to postsynaptic membrane |
| regulation of NMDA receptor activity |
| receptor localization to synapse |
| establishment or maintenance of epithelial cell apical/basal polarity |
| receptor clustering |
| regulation of postsynaptic membrane neurotransmitter receptor levels |
| establishment or maintenance of bipolar cell polarity |
| establishment or maintenance of apical/basal cell polarity |
| establishment of protein localization to plasma membrane |
| specific granule lumen |
| protein localization to synapse |
| regulation of glutamate receptor signaling pathway |
| regulation of neurotransmitter receptor activity |
| localization within membrane |
| vesicle-mediated transport to the plasma membrane |
| cell-cell adherens junction |
| cell-cell junction |
| regulation of cation channel activity |
| regulation of signaling receptor activity |
| protein localization to plasma membrane |
| establishment or maintenance of cell polarity |
| basolateral plasma membrane |
| postsynaptic membrane |
| endosomal transport |
| protein localization to cell periphery |
| postsynaptic density |
| protein-containing complex localization |
| regulation of ion transmembrane transporter activity |
| establishment of protein localization to membrane |
| regulation of transmembrane transporter activity |
| synapse |
| regulation of transporter activity |
| positive regulation of neuron projection development |
| neuron projection |
| regulation of cation transmembrane transport |
| positive regulation of neuron differentiation |
| MAPK cascade |
| positive regulation of cell projection organization |
| signal transduction by protein phosphorylation |
| establishment of protein localization to organelle |
| positive regulation of neurogenesis |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| regulation of neuron projection development |
| neutrophil mediated immunity |
| neutrophil activation |
| cell-cell adhesion |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| positive regulation of nervous system development |
| positive regulation of cell development |
| cell junction |
| regulation of transmembrane transport |
| myeloid leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of ion transport |
| regulated exocytosis |
| regulation of cell projection organization |
| protein localization to organelle |
| leukocyte mediated immunity |
| exocytosis |
| regulation of neurogenesis |
| regulation of nervous system development |
| leukocyte activation |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| positive regulation of cell differentiation |
| protein phosphorylation |
| intracellular protein transport |
| secretion by cell |
| export from cell |
| cell activation |
| immune effector process |
| secretion |
| positive regulation of cellular component organization |
| phosphorylation |
| positive regulation of developmental process |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-2536 0.001μM R01 exp41 | 1.75 |
| Daidzin 10μM R06 exp280 | 1.93 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17393
- Expression level (log2 read counts): 3.87
Expression Distribution
LRRC7 Expression in NALM6 Cells: 3.87
